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Updated: Jun 26, 2026

Compact Quantum Dots for Single-molecule Imaging
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Biomass-derived surface-functionalized graphene quantum dots for aggregation-induced green fluorescence.

Syed Adil Shah1, Eman Gul2, Syed Niaz Ali Shah3

  • 1School of Biomedical Engineering, Health Science Centre, Shenzhen University Shenzhen Guangdong 518060 PR China syedshahkhan2141@gmail.com.

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|November 27, 2025
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Researchers synthesized nitrogen-doped graphene quantum dots (GQDs) from biomass. Surface functionalization enhanced their green fluorescence and introduced defects, showing potential for displays and cancer drug delivery.

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Area of Science:

  • Nanomaterials Science
  • Materials Chemistry
  • Biomedical Engineering

Background:

  • Surface modification and vacancy defects significantly impact nanomaterial properties.
  • Understanding defect dynamics in graphene quantum dots (GQDs) is crucial but challenging.
  • Atomically thin GQDs with controlled defects are underexplored.

Purpose of the Study:

  • To synthesize and characterize nitrogen-doped GQDs from biomass.
  • To investigate the effects of surface functionalization on GQD defects and fluorescence.
  • To explore potential applications in displays and cancer therapeutics.

Main Methods:

  • Synthesis of nitrogen-doped GQDs from biomass extracts.
  • Surface functionalization of GQDs.
  • Characterization using UV-vis, FTIR, dark-field STEM, and X-ray photoelectron spectroscopy.
  • Luminescence studies (fluorescence and photoluminescence).

Main Results:

  • Successful synthesis of ~3 nm nitrogen-doped GQDs.
  • Surface functionalization introduced inner defects and promoted GQD aggregation.
  • Significant enhancement of green fluorescence observed.
  • Characterization confirmed GQD structure, defects, and functional groups.

Conclusions:

  • Surface-functionalized GQDs exhibit enhanced luminescence due to introduced defects and aggregation.
  • These GQDs are promising for high-performance display applications due to their semiconducting nature.
  • Their biocompatibility and fluorescence make them suitable for drug delivery, especially in cancer therapy.