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Related Experiment Video

Updated: Jan 10, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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Aptamers in Drug Delivery Development.

Connie Wen1, Yixun Wang1, Yong Wang1

  • 1Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.

Materials Today (Kidlington, England)
|November 27, 2025
PubMed
Summary

Aptamers, or "chemical antibodies," are versatile nucleic acids with high-affinity binding. This review explores their diverse therapeutic uses and challenges in drug delivery systems.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Drug Delivery Systems

Background:

  • Aptamers are short, single-stranded nucleic acids that mimic antibodies.
  • They exhibit high affinity and specificity for target molecules.
  • This makes them promising tools in various biomedical applications.

Purpose of the Study:

  • To review the diverse therapeutic applications of aptamers.
  • To discuss the use of aptamers in standalone drug therapy.
  • To explore aptamers as carriers for various therapeutics and in functionalizing drug delivery systems.

Main Methods:

  • Literature review of aptamer applications in therapeutics and drug delivery.
  • Analysis of aptamer-based drug delivery systems, including nanoparticles and biomaterials.
Keywords:
AptamerDrug DeliveryHydrogelsNanoparticles

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  • Discussion of challenges and future directions.

    • Main Results:

    • Aptamers can act as standalone drugs.
    • They serve as effective carriers for small molecules, nucleic acids, peptides, proteins, and antibodies.
    • Aptamers can functionalize nanoparticles and bulk biomaterials for targeted delivery.

    Conclusions:

    • Aptamers offer versatile therapeutic potential due to their specific binding properties.
    • Their application in drug delivery systems, including nanoparticles, is expanding.
    • Addressing challenges is crucial for the successful clinical translation of aptamer-based therapies.