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Updated: Jan 10, 2026

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Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
Published on: November 27, 2013
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Rising Millifluidics: A Practical Approach Towards Wide Application.
1School of Intelligent Science and Technology, Nanjing University of Science & Technology, Nanjing, China.
Critical Reviews in Analytical Chemistry
|November 27, 2025
Summary
Millifluidic devices offer a low-cost, high-throughput alternative to microfluidics for handling liquids. These millimeter-scale devices are more accessible and visible, expanding applications in chemical and biomedical fields.
Area of Science:
- Engineering
- Chemistry
- Biomedical Sciences
Background:
- Millifluidics extends microfluidic technology to the millimeter scale.
- It offers advantages like low cost, high throughput, and visible fluid flow.
- Millifluidic devices are more accessible to researchers across various disciplines.
Purpose of the Study:
- To provide a comprehensive review of millifluidic devices.
- To highlight their advantages and applications compared to microfluidics.
- To explore emerging trends such as AI integration.
Main Methods:
- Literature review of millifluidic devices and their applications.
- Comparison of millifluidic and microfluidic technologies.
- Analysis of recent advancements and future potential.
Main Results:
- Millifluidics provides a low-cost, high-throughput, and accessible platform.
- Applications overlap with microfluidics, including reactions, synthesis, and detection.
- Millifluidics is partially replacing microfluidics in areas like particle synthesis.
- AI and machine learning are increasingly used for design and control.
Conclusions:
- Millifluidic devices present a viable, accessible, and efficient solution for various scientific fields.
- They offer a promising alternative for real-world tasks in chemical, biomedical, and environmental applications.
- The integration of AI and machine learning signifies future advancements in millifluidic technology.
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