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EBV-Positive Diffuse Large B-Cell Lymphoma (DLBCL): An Assessment and a Roadmap
Pierluigi Porcu1, Rebecca Masel2, Nicholas Kendsersky3
1Division of Hematology and BMT, Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.
Journal of Medical Virology
|November 27, 2025
Summary
Epstein-Barr Virus (EBV) is found in 5-15% of Diffuse Large B-cell Lymphoma (DLBCL) cases. EBV-positive DLBCL has unique features and EBV is a prognostic biomarker, with ongoing research into targeted therapies.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Diffuse Large B-cell Lymphoma (DLBCL) is the most common lymphoma globally.
- Epstein-Barr Virus (EBV) is linked to various human cancers.
- EBV DNA is present in 5-15% of DLBCL tumors in immunocompetent individuals.
Purpose of the Study:
- To review current clinical and molecular data on EBV-positive DLBCL.
- To discuss novel therapeutic strategies targeting EBV in DLBCL.
- To identify key unanswered questions in EBV-positive DLBCL research.
Main Methods:
- Literature review of recent clinical and molecular studies on EBV-positive DLBCL.
- Analysis of the impact of modern chemo-immunotherapy on EBV-positive DLBCL.
- Exploration of the distinct mutational landscape and immune microenvironment.
Main Results:
- EBV-positive DLBCL exhibits distinct clinical features, tumor microenvironment (TME), and historically, poorer survival.
- Modern treatments have refined the understanding and outcomes of EBV-positive DLBCL.
- EBV is confirmed as an independent prognostic biomarker in DLBCL.
Conclusions:
- EBV-positive DLBCL is a distinct clinicopathological entity.
- Further research is crucial for developing targeted EBV therapies.
- Understanding EBV's role is key to improving DLBCL patient outcomes.
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