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Maternal Myo-Inositol Intake and Congenital Heart Defects in Offspring: A Population-Based Case-Control Study.

Ruiqi Cen1, L Joseph Su2, Jun Ying3

  • 1Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

BJOG : an International Journal of Obstetrics and Gynaecology
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Maternal intake of myo-inositol supplements during early pregnancy may reduce the risk of congenital heart defects (CHDs) in infants. Higher total myo-inositol intake from diet and supplements is associated with lower odds of specific CHDs.

Keywords:
congenital heart defectsfolic acidmyo‐inositol

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Area of Science:

  • Reproductive Health
  • Pediatric Cardiology
  • Nutritional Epidemiology

Background:

  • Congenital heart defects (CHDs) are a significant concern in pediatric health.
  • Myo-inositol is a naturally occurring compound found in foods and supplements.
  • Periconceptional nutritional status plays a crucial role in fetal development.

Purpose of the Study:

  • To examine the relationship between maternal myo-inositol intake around conception and the likelihood of offspring having CHDs.
  • To assess associations with specific types of CHDs, including septal defects and outflow tract defects.

Main Methods:

  • Population-based case-control study utilizing the National Birth Defects Prevention Study (NBDPS) database in the United States.
  • Inclusion of over 11,000 cases with CHDs and 11,000 controls without major birth defects.
  • Assessment of myo-inositol intake via food frequency questionnaires and surveys, analyzed using logistic regression models.

Main Results:

  • Maternal use of myo-inositol supplements was linked to reduced odds of selected CHDs overall (aOR=0.79) and septal defects (aOR=0.61).
  • Higher total myo-inositol intake (≥500 mg/day) was associated with decreased odds for CHDs as a group (aOR=0.88) and specific types like conotruncal defects (aOR=0.87).

Conclusions:

  • Maternal myo-inositol intake during the periconceptional period shows an inverse association with the risk of selected congenital heart defects in offspring.
  • These findings suggest a potential protective role for myo-inositol in preventing certain CHDs.