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A dual-mode viscosity-activatable probe for the immediate evaluation of photodynamic/photothermal therapy efficacy
Ao-Xiang Fu1, Li Li1, Qin-Ting Liao1
1Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Hunan Provincial University Key Laboratory for Environmental and Ecological Health, College of Chemistry, Xiangtan University, Xiangtan, 411105, P. R. China. xufen@xtu.edu.cn.
Abstract:
A dual-mode probe, named BC-V, is constructed for viscosity imaging. In high-viscosity solution, the fluorescence and photoacoustic signals are triggered. Under laser irradiation, the photodynamic and photothermal properties are activated. Furthermore, during phototherapy in tumor-bearing mice, therapy efficacy can be immediately evaluated using dual-mode imaging.
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