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EndoCompass Project: Endocrinology across the Lifespan
Evelien F Gevers1,2, Martine Cools3,4, Anita C Hokken-Koelega5
1Centre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK, evelien.gevers@nhs.net.
Hormone Research in Paediatrics
|November 27, 2025
Summary
Endocrine science research needs strategic prioritization across all life stages, from conception to aging. The EndoCompass project identified key research areas to address hormone health challenges and Europe
Area of Science:
- Endocrinology and hormone health research.
- Lifespan approaches to endocrine science.
- European research policy and funding.
Background:
- Endocrine science is under-represented in European Union (EU) research programs.
- A gap exists between the societal impact of endocrine disorders and research prioritization.
- National funding often overlooks endocrinology, despite its importance.
Purpose of the Study:
- To identify and promote strategic research priorities in endocrine science.
- To address critical hormone-related health challenges.
- To develop a roadmap for endocrine research across the lifespan.
Main Methods:
- Analysis of the EU CORDIS database for Horizon 2020 (2014-2020).
- Expert analysis of endocrine regulation and health from gametogenesis to aging.
- Integration of evidence across developmental stages.
Main Results:
- Key priorities include epigenetic programming, developmental origins of adult disease, brain-gut communication, and healthy aging.
- Emphasis on critical developmental windows and transgenerational effects.
- Need for integrated research spanning pediatric and adult endocrinology.
Conclusions:
- Provides an evidence-based roadmap for hormone regulation across life stages.
- Highlights the need for coordinated, lifespan research to address demographic challenges.
- Supports strategic investment in comprehensive endocrine health approaches.
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