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Related Concept Videos

Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Temperature-Responsive, Injectable Poly(organophosphazene)-Based Hydrogel Adhesive for One-Step Hemostasis and Wound

Jisun Kim1,2, Jun Kim1, Jiyeon Lee1,3

  • 1Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

Biomacromolecules
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

A new injectable hydrogel adhesive, ADP-PPZ, offers improved hemostasis and wound closure. This single-component system gels at body temperature and adheres strongly to tissues, outperforming existing PEG-based adhesives.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Injectable hydrogel adhesives are promising for wound closure and hemostasis due to minimally invasive application.
  • Current hydrogels face limitations including insufficient mechanical strength, weak adhesion, and complex application procedures.
  • There is a need for advanced hydrogel adhesives with enhanced performance for surgical and emergency settings.

Purpose of the Study:

  • To develop a novel single-component, thermoresponsive hydrogel adhesive with improved mechanical properties and adhesion.
  • To investigate the gelation mechanism and tissue adhesion capabilities of the proposed poly(organophosphazene)-based hydrogel.
  • To evaluate the efficacy of the hydrogel adhesive in hemostasis, wound sealing, and tissue regeneration compared to existing materials.

Main Methods:

  • Synthesis of a poly(organophosphazene) backbone functionalized with succinimidyl carbonate (SC) groups, creating the ADP-PPZ hydrogel.
  • Characterization of hydrogel properties including gelation time, mechanical strength, adhesion strength (23 kPa), swelling behavior, biocompatibility, and biodegradability.
  • In vivo evaluation of ADP-PPZ for hemostasis, tissue sealing, and promotion of re-epithelialization and collagen remodeling, with comparisons to PEG-based adhesives.

Main Results:

  • ADP-PPZ demonstrated rapid gelation at body temperature (5.5 seconds) via hydrophobic interactions, without external triggers.
  • The hydrogel exhibited robust mechanical strength and effective tissue adhesion, alongside low swelling and proven biocompatibility and biodegradability.
  • ADP-PPZ showed superior performance in hemostasis, stable tissue sealing, and enhanced tissue regeneration (re-epithelialization, collagen remodeling) compared to PEG-based controls.

Conclusions:

  • ADP-PPZ represents a novel single-component hydrogel adhesive design enabling independent gelation and tissue adhesion.
  • The developed hydrogel adhesive offers significant advantages over current systems, addressing limitations in mechanical strength and adhesion.
  • ADP-PPZ shows considerable potential for applications in hemostasis and regenerative medicine, particularly in surgical and emergency wound management.