Selective alkaloid extraction from functional foods via tailored deep eutectic solvent-alkaline electrolyzed water
Fuhui Luo1, Zhongqiao Zhao1, Yong He1
1Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China.
Abstract:
Nelumbinis Plumula, a dual-use medicinal and edible plant, has been processed into a functional drinks and exhibits pharmaceutical potential via bioactive compounds. Here, a new solvent system composed of alkaline electrolyzed water (AEW) and deep eutectic solvents (DES) (AEWDES) has been developed. Screening 30 solvents revealed AEWDESs (L-proline-1-methylurea) (LP-JJN) outperformed ultrasound assisted DESs and traditional solvents in extraction efficiency. We propose a novel hybrid framework integrating Crested porcupine optimizer-Backpropagation neural networks-Sparrow search algorithm (CPO-BP-SSA) for alkaloids extraction optimization. The yield enhancement primarily stems from AEWDES-mediated cell wall disruption increasing compound accessibility and augmented intermolecular interactions (hydrogen bonding, Van Der Waals force) between target alkaloids and DES components. Green metrics validated the method's sustainability. AEWDES extraction method is universal and can serve as a reference for the extraction of various alkaloids. Future research should prioritize the recovery of alkaloids compounds through advanced extraction and desorption techniques.
Related Concept Videos
00:56Extraction: Advanced Methods
01:30Capillary Electrophoresis: Applications
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
01:26Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...