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RSV-associated hospitalizations in Bangladeshi children under five: Unveiling the disease burden

Mst Noorjahan Begum1, Yeasir Karim1, Sabik Khair1

  • 1Virology Laboratory, Infectious Diseases Division, icddr,b: International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka 1212, Bangladesh.

Journal of Infection and Public Health
|November 27, 2025
PubMed

Insights

Respiratory Syncytial Virus (RSV) significantly impacts hospitalized children under five in Bangladesh, particularly infants under six months with severe acute respiratory infections (SARI). Findings underscore the need for targeted control measures to reduce RSV-related hospitalizations.

Area of Science:

  • Pediatrics
  • Virology
  • Public Health

Background:

  • Respiratory Syncytial Virus (RSV) is a major global cause of severe respiratory illness in young children.
  • Limited data exist on RSV prevalence in Bangladeshi children under five.
  • This study addresses the knowledge gap regarding RSV burden in this vulnerable population in Bangladesh.

Purpose of the Study:

  • To estimate the prevalence of RSV in hospitalized Bangladeshi children under five.
  • To analyze RSV distribution by age, sex, and geographic region.
  • To inform targeted public health interventions for RSV prevention and control.

Main Methods:

  • Hospital-based surveillance of children with Severe Acute Respiratory Infections (SARI) or Influenza-Like Illness (ILI).
  • Real-time RT-PCR used for RSV detection from nasopharyngeal and oropharyngeal swabs.
  • Statistical analysis including descriptive statistics, chi-square tests, and logistic regression.

Main Results:

  • RSV was detected in 2758 out of 8203 enrolled children (33.6%).
  • Prevalence was higher in SARI cases (36%) versus ILI cases (16%).
  • Infants under six months had the highest prevalence (44%), decreasing with age; RSV seasonality peaks October-December.

Conclusions:

  • A significant RSV burden exists among Bangladeshi children under six months with SARI.
  • Age-specific control strategies are crucial for reducing RSV-related hospitalizations.
  • Findings support the development of targeted interventions for high-risk pediatric populations.
Abstract

Keywords:
BangladeshChildrenILIRSVRespiratory Syncytial VirusSARI

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