Multiple African-origin circulating poliovirus-2 emergences identified in Israel: A reminder of an ongoing global challenge
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View abstract on PubMed
Summary
This summary is machine-generated.Two vaccine-derived poliovirus type 2 (cVDPV2) strains were detected in Israeli wastewater in early 2025. These strains, linked to African emergences, highlight the global risk and need for environmental surveillance.
Area Of Science
- Environmental microbiology
- Virology
- Public health
Background
- Vaccine-derived poliovirus (VDPV) strains can cause acute flaccid paralysis (AFP).
- VDPVs pose a significant threat to global poliovirus eradication efforts.
- Ongoing environmental surveillance is crucial for detecting poliovirus circulation.
Purpose Of The Study
- To report the detection of two distinct circulating VDPV type 2 (cVDPV2) strains in Israel.
- To genetically characterize these strains and determine their origins.
- To emphasize the importance of environmental surveillance in early detection and response.
Main Methods
- Wastewater sampling and environmental surveillance.
- Whole-genome sequencing (WGS) for genetic analysis.
- Phylogenetic analysis to determine strain relationships and origins.
Main Results
- Two distinct cVDPV2 strains were identified in wastewater samples from central Israel and Jerusalem in January and February 2025.
- The first strain was genetically linked to the NIE-ZAS-1 emergence in Africa.
- The second strain was related to the SUD-RED-1 emergence in Africa, indicating international importation events.
Conclusions
- The detection of imported cVDPV2 strains in Israel underscores the global risk of poliovirus importation.
- Environmental surveillance plays a critical role in the early detection of VDPVs.
- Genomic data aids in tracking the international spread of VDPV strains.
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