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Protective Effect of Boldine Against Diclofenac-Induced Renal Damage in Rats
Luísa Nathália Bolda Mariano1, Heloísa Roberti Cristofolini2, Rita de Cássia Vilhena da Silva1
1Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Brazil.
Boldine, an alkaloid, protects against diclofenac-induced kidney damage in rats by restoring urinary function and reducing histological damage. This suggests boldine
Area of Science:
- Pharmacology
- Nephrology
- Toxicology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac can cause kidney damage.
- Investigating natural compounds for renoprotective effects is crucial.
Purpose of the Study:
- To evaluate the protective effect of boldine against diclofenac-induced nephrotoxicity in rats.
- To explore the potential mechanisms underlying boldine's renoprotective action.
Main Methods:
- Rats were treated with diclofenac alone or in combination with boldine.
- Urinary parameters, plasma analysis, kidney tissue markers, and histology were assessed.
- Molecular docking was used to predict interactions between boldine and renal proteins.
Main Results:
- Boldine treatment restored urinary volume and sodium excretion in diclofenac-treated rats.
- Kidney tissue showed increased glutathione and decreased lipid hydroperoxides with boldine.
- Histological analysis revealed less pronounced renal damage in rats co-treated with boldine.
Conclusions:
- Boldine exhibits significant renoprotective effects against diclofenac-induced kidney damage.
- Boldine may act through multiple targets involved in renal hemodynamics, sodium regulation, and inflammation.
- Further research is warranted to fully elucidate boldine's mechanisms and therapeutic potential.
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