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Sim-to-real domain adaptation based completion level recognition for autonomous micro-drilling in biomedical
Enduo Zhao1,2, Saul Alexis Heredia Perez3, Kanako Harada3
1Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8654, Japan. endowzhao@mail.tsinghua.edu.cn.
Scientific Reports
|November 28, 2025
Summary
This study enhances autonomous micro-drilling for surgery by using a novel simulation-to-real model. This approach significantly reduces annotation time and improves drilling accuracy, making it more practical for biomedical applications.
Area of Science:
- Biomedical Engineering
- Robotics
- Computer Vision
Background:
- Micron-level precision drilling in bone is crucial for surgical and neuroscience applications.
- Current manual and imaging-based methods face limitations in speed, accuracy, and adaptability.
- Previous autonomous systems relied on manual annotation, hindering scalability and performance.
Purpose of the Study:
- To enhance an autonomous micro-drilling system using simulation-to-real domain adaptation.
- To reduce the reliance on manual annotation and improve system accuracy and scalability.
- To validate the effectiveness of a task-specific adversarial model for bridging the sim-to-real gap.
Main Methods:
- Developed a photorealistic simulator to generate synthetic data for training.
- Implemented a task-specific adversarial model for domain adaptation.
- Trained and tested the enhanced system on eggshell drilling tasks.
Main Results:
- Annotation time reduced from 600 s/frame to 1.8 s/frame.
- Drilling success rate improved from 80% to 85% over 20 trials.
- Demonstrated significant reduction in the domain gap between simulated and real-world data.
Conclusions:
- Simulation-based training combined with domain adaptation effectively improves autonomous micro-drilling.
- The novel adversarial model enhances system performance and reduces manual annotation burden.
- This approach shows promise for advancing precision drilling in biomedical applications.

