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Updated: Jan 10, 2026

Assembly and Quantification of Co-Cultures Combining Heterotrophic Yeast with Phototrophic Sugar-Secreting Cyanobacteria
Published on: December 27, 2024
Advances and Future Perspectives of Synechocystis sp. as a Microbial Cell Factory for Biomanufacturing
Hehe He1,2, Kun Gao1,2, Bifei Mao1,2
1Jiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, China.
Abstract:
Synechocystis sp., a prominent model organism among cyanobacteria, is renowned for its efficient CO2 utilization to produce valuable metabolites, positioning it as a promising alternative to traditional heterotrophic microbes for sustainable bioproduction. Recent advances in Synechocystis-based cell factories have significantly improved synthetic biology design and the bioproduction of high-value biochemicals. In this review, we provide an updated bioinformatics overview of Synechocystis sp. and comprehensively summarize the latest advancements in its synthetic biology applications. Additionally, we highlight recent progress and challenges in scaling up and industrialization, while proposing future research directions, including the integration of omics strategies. These developments are expected to drive the application of cyanobacteria in industrial biotechnology and contribute to the advancement of sustainable, low-carbon, and high-efficiency bioproduction systems.
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