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Patchoulol: Bioactive Properties, Synthase Catalytic Mechanisms, and Biosynthetic Progress ── a Review
Shengxin Nie1,2,3, Pengyuan Wang1,2,3, Mingyue Ge1,2,3
1State Key Laboratory of Synthetic Biology, Tianjin University, Tianjin 300072, China.
ACS Synthetic Biology
|November 28, 2025
Summary
Biosynthesis offers a promising alternative to traditional phytoextraction for producing patchoulol, a valuable sesquiterpene alcohol. This review explores patchoulol
Area of Science:
- Biotechnology
- Metabolic Engineering
- Natural Product Synthesis
Background:
- Patchoulol, a tricyclic sesquiterpene alcohol, has diverse applications in perfumery, cosmetics, and medicine.
- Traditional phytoextraction methods for patchoulol production are limited by natural resource availability and low efficiency.
Purpose of the Study:
- To review the biological properties and biosynthesis of patchoulol.
- To explore advancements in patchoulol synthase mechanisms and metabolic engineering strategies.
- To discuss the application prospects and future research directions for patchoulol production.
Main Methods:
- Literature review of patchoulol biosynthesis and metabolic engineering.
- Analysis of patchoulol synthase cyclization mechanisms.
- Evaluation of synthetic biology approaches for enhanced production.
Main Results:
- Patchoulol exhibits significant biological activities and industrial potential.
- Biosynthesis via synthetic biology presents a viable alternative to phytoextraction.
- Understanding of patchoulol synthase mechanisms is advancing.
Conclusions:
- Metabolic engineering and synthetic biology offer scalable and efficient routes for patchoulol production.
- Further research into biosynthesis can unlock broader applications for patchoulol.
- Optimized biosynthetic strategies are crucial for industrial viability.
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