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Principles of oncology
Bryan J Neth1, Jing Zhao2, Kevin T Nead2,3
1Department of Neurology and Medical Oncology, Mayo Clinic, Rochester, MN, USA.
Journal of Clinical and Experimental Neuropsychology
|November 28, 2025
Summary
Cancer survivorship is improving, but cognitive dysfunction remains a challenge for many patients. Further research is needed to understand risk factors and develop effective treatments for cancer-related cognitive impairment.
Area of Science:
- Oncology
- Cancer Survivorship Research
- Neuro-oncology
Background:
- Cancer is a major global health issue with millions of new cases annually.
- Advances in cancer prevention and treatment are increasing survival rates.
- Cognitive dysfunction is a prevalent symptom impacting cancer survivors' quality of life.
Purpose of the Study:
- To provide a comprehensive overview of cancer epidemiology, risk factors, and biology.
- To discuss mechanisms and side effects of various cancer therapies.
- To review central nervous system tumors and treatment considerations.
Main Methods:
- Literature review and synthesis of existing research.
- Overview of cancer incidence, mortality, and survival trends.
- Discussion of therapeutic modalities and their associated toxicities.
Main Results:
- Cancer mortality is declining due to progress in care.
- Cognitive dysfunction is a significant long-term symptom for survivors.
- Understanding of cancer biology and treatment side effects is advancing.
Conclusions:
- Continued research is essential for managing cancer-related cognitive dysfunction.
- Improved supportive care and symptom management are crucial for cancer survivors.
- This review serves as a foundation for further investigation into cancer survivorship challenges.
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