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Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy
Published on: June 27, 2013
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Non-contact electrochemical imaging of Young's modulus of single living cells
Rong Jin1,2, Yanyan Xu1,3, Kang Wang1
1State Key Laboratory of Analytical for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China. dechenjiang@nju.edu.cn.
Chemical Communications (Cambridge, England)
|November 28, 2025
Abstract:
A non-contact electrochemical imaging method based on hydrodynamic resistance is developed to image the apparent Young's modulus of living cells. This strategy realizes nanometer cell deformation and high-resolution 3D modulus mapping with minimal disturbance to living cells and further reveals the cytoskeleton-associated modulus distribution in migrating cells.
