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New Stent Retriever Technology Versus Standard Devices for Anterior Large Vessel Thrombectomy: A Multicenter Study
Josep Puig1, Guillem Dolz2, Mariano Werner2
1Radiology Department CDI, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain.
Summary
The iNtercept stent retriever is non-inferior to contemporary stent retrievers for large vessel occlusion stroke reperfusion. This study found similar outcomes and fewer complications with iNtercept in acute ischemic stroke treatment.
Area of Science:
- Neuroendovascular therapy
- Cerebrovascular diseases
- Medical devices
Background:
- Guidelines recommend stent retrievers (SRs) for large vessel occlusion (LVO) stroke.
- The iNtercept SR is a newer device with a self-expanding basket design.
Purpose of the Study:
- To assess the non-inferiority of the iNtercept SR compared to contemporary SRs (CSRs).
- To evaluate procedural, clinical, and safety outcomes in LVO stroke patients.
Main Methods:
- Propensity score (PS) matching analysis of the ROSSETTI multicenter registry data.
- Comparison of iNtercept versus CSRs (Solitaire, Trevo, EmboTrap) as first-line treatment.
- Outcomes assessed: reperfusion (mTICI), clinical (mRS), and safety (sICH, mortality).
Main Results:
- Successful reperfusion (mTICI2b/3) rates were similar between iNtercept and CSRs (with or without balloon-guide catheter).
- Favorable 90-day outcomes were comparable between groups.
- iNtercept showed fewer symptomatic intracranial hemorrhages and procedural complications compared to CSRs, particularly when used with a balloon-guide catheter.
Conclusions:
- The iNtercept stent retriever is non-inferior to approved CSRs for successful reperfusion in LVO acute ischemic stroke.
- iNtercept offers comparable efficacy with a potentially improved safety profile.
