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A Delayed Foreign Body Reaction to a Hemostatic Agent Mimicking Neoplasm.

Silvija Milanovic¹, Christina Sun², Tricia A Missall²

¹Department of Medicine, University of Florida College of Medicine, Gainesville, USA.

|November 28, 2025

Summary

Delayed foreign body reactions to hydrophilic polymer hemostatic agents containing potassium ferrate can mimic other skin conditions. Recognizing these distinct histologic features is crucial for accurate diagnosis and management in dermatologic surgery.

Area of Science:

Dermatopathology
Surgical Pathology
Wound Healing

Keywords:

dermato-pathology foreign body reaction hemostatic agent hydrophilic polymer potassium ferrate

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Background:

Hydrophilic polymer-based hemostatic agents with potassium ferrate are utilized in dermatologic surgery for their rapid, coagulation-independent hemostasis.
These agents are generally considered safe, but delayed foreign body reactions are an underrecognized complication.
Such reactions can clinically mimic neoplastic recurrence, hypertrophic scarring, or cyst formation, posing diagnostic challenges.