Epigenetic programming reshapes innate immune memory: decoding the molecular imprint of gouty inflammation
Wenjie Su1,2, Yifan Lu1,3, Zhiqiang Luo4
1Hunan University of Chinese Medicine, Changsha, Hunan, China.
Frontiers in Pharmacology
|November 28, 2025
Summary
Epigenetic modifications and trained immunity are key to understanding gout pathogenesis. Targeting these epigenetic changes offers potential new therapeutic strategies for gout treatment.
Area of Science:
- Rheumatology
- Immunology
- Genetics
Background:
- Gout is an inflammatory joint disease driven by abnormal uric acid metabolism and urate crystal deposition.
- Current gout treatments lack ideal efficacy due to complex etiology and pathogenesis.
- Epigenetic modifications regulate gene expression and cellular functions, impacting physiological and pathological states.
Purpose of the Study:
- To review the latest findings on epigenetic modifications in gout development.
- To explore the role of epigenetic remodeling in trained immunity within gout.
- To discuss potential epigenetic intervention strategies for gout management.
Main Methods:
- Literature review of recent research on epigenetics and gout.
- Analysis of epigenetic mechanisms (DNA methylation, histone modifications, non-coding RNA).
- Examination of the interplay between epigenetics, trained immunity, and inflammation in gout.
Main Results:
- Epigenetic modifications play a significant role in gout pathogenesis.
- Trained immunity, mediated by epigenetic remodeling, is a novel area in gout research.
- Epigenetic mechanisms influence persistent inflammation and innate immune memory in gout.
Conclusions:
- Epigenetic modifications are crucial in gout development and progression.
- Epigenetic remodeling-mediated trained immunity offers new insights into gout pathogenesis.
- Epigenetic interventions represent a promising frontier for future gout therapies.
Keywords:
DNA methylationacetylationepigenetic reprogramminggouthistonemodificationnon-coding RNAtrained immunityMore Related Videos
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