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Related Experiment Video

Updated: May 6, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Atomically Precise Metal Nanoclusters for Bioimaging and Therapy: Progress and Perspectives.

Tingting Xu¹, Beibei Xiang¹, Yu Chen¹

¹School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, P. R. China.

|November 28, 2025

Summary

Atomically precise metal nanoclusters (MNCs) offer combined bioimaging and therapeutic capabilities. Their small size and tunable properties enable precise disease detection and treatment, improving patient outcomes.

Keywords:

Atomically precise metal nanoclusters bioimaging physicochemical properties therapy

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Area of Science:

Nanomedicine
Biomaterials
Theranostics

Background:

Atomically precise metal nanoclusters (MNCs) are ultrasmall (<3 nm) and monodisperse nanomaterials.
MNCs possess unique properties like efficient renal clearance, excellent biocompatibility, and tunable near-infrared photoluminescence.

Purpose of the Study:

To explore the potential of MNCs for simultaneous bioimaging and therapeutic applications.
To highlight the advantages of MNCs in early disease detection and precise therapy.

Main Methods:

Review of the biological properties and applications of MNCs.
Discussion of ligand-engineering and alloying strategies for MNCs.
Analysis of MNCs' photoluminescence, photostability, and catalytic activities.

Main Results:

MNCs exhibit superior photoluminescence in the near-infrared region with high sensitivity and deep tissue penetration.
MNCs can be utilized for various therapies including photothermal, photodynamic, chemodynamic, and radiotherapy.
Ligand-engineering and alloying enable imaging-guided precise therapy using MNCs.

Conclusions:

MNCs are promising theranostic agents with excellent biocompatibility and versatile functionalities.
Further research and multidisciplinary efforts are needed to advance MNC applications in biomedicine.