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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Teaching water new tricks through boron coordination: Applications to green and sustainable synthesis
Allen Alonso Rodríguez Ugalde1, Steven Bloom1
1Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, 66045, USA.
Abstract:
Water has been widely explored as a solvent and/or proton source for the development of green chemical technologies. However, water has the capacity to take on more interesting roles by coordinating with a Lewis acidic boron atom. These aquaboryl complexes uniquely activate the O-H bond of water, making it a competent reducing agent, hydrogen atom transfer reagent, strong chiral acid, bifunctional hydrogen bond donor, or proton-coupled electron transfer mediator. Herein, we discuss each of these potential roles in more detail and present relevant examples regarding their applications for modern sustainable synthesis.
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