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Updated: Jul 1, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

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Association between white matter microstructural and functional abnormalities and clinical characteristics in

Qixuan Fu1, Chaorong Xie1, Yangxu Ou1

  • 1School of Acupuncture Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Frontiers in Neurology
|November 28, 2025
PubMed
Abstract

Insights

Migraine without aura (MWoA) patients show altered white matter (WM) microstructure and function, particularly in the corpus callosum and left frontopontine regions. These changes correlate with disease duration and intensity, offering insights into MWoA pathophysiology.

Area of Science:

  • Neuroscience
  • Radiology
  • Neurology

Background:

  • Migraine without aura (MWoA) is linked to white matter (WM) abnormalities.
  • The interplay between clinical features and WM microstructure/function in MWoA requires further investigation.

Purpose of the Study:

  • To investigate associations between clinical characteristics and WM microstructural/functional abnormalities in MWoA.
  • To enhance understanding of MWoA pathophysiology.

Main Methods:

  • 51 MWoA patients and 51 healthy controls (HCs) underwent MRI.
  • Tract-based spatial statistics (TBSS) assessed WM microstructure.
  • Amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC) evaluated functional alterations.
  • Spearman's rank correlation analyzed associations with clinical data.

Main Results:

  • MWoA patients exhibited reduced fractional anisotropy (FA), axial dispersion (AD), and DC, alongside increased ALFF in the left frontopontine (FPT_L).
  • Reduced FA and AD were observed in the forceps major (CC_ForcepsMajor), and decreased ALFF in the forceps minor (CC_ForcepsMinor).
  • WM abnormalities in FPT_L and CC_ForcepsMajor correlated with disease duration and visual analog scale (VAS) scores, respectively.

Conclusions:

  • Concomitant WM function and microstructure alterations exist in CC subregions and FPT_L in MWoA patients.
  • These abnormalities correlate significantly with clinical characteristics.
  • WM integrity and functional fluctuations may mediate the link between network integration and disease duration in MWoA.
Keywords:
amplitude of low-frequency fluctuationdegree centralitypaintract-based spatialstatisticswhite matter tracts

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