Prevalence of neurodevelopmental disorders in children with chronic hepatitis C in British Columbia
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View abstract on PubMed
Summary
This summary is machine-generated.A majority of children with chronic hepatitis C (HCV) have neurodevelopmental disorders. This study highlights a significant issue in pediatric HCV care, emphasizing the need for early identification and support for affected children.
Area Of Science
- Pediatric Hepatology
- Neurodevelopmental Pediatrics
- Public Health
Background
- Chronic hepatitis C (HCV) in children is mainly due to vertical transmission.
- Maternal intravenous drug use, a risk factor for HCV, is linked to neurodevelopmental issues in offspring.
- Prevalence of neurodevelopmental disorders in pediatric HCV patients is largely unexplored.
Purpose Of The Study
- To investigate the occurrence of neurodevelopmental disorders in children diagnosed with chronic hepatitis C.
- To understand the spectrum of learning and developmental difficulties in this population.
Main Methods
- Retrospective chart review of pediatric patients with chronic HCV.
- Data collection included demographic, clinical information, and diagnoses of neurodevelopmental disorders.
- Study period: December 2020 to April 2024 in British Columbia.
Main Results
- 29 children (under 18) with chronic HCV were identified; 28 vertically infected.
- 62% (18/29) had at least one neurodevelopmental disorder or learning difficulty.
- Attention deficit hyperactivity disorder (ADHD) affected 48% (14/29), with co-occurring fetal alcohol spectrum disorder (FASD) and autism spectrum disorder (ASD).
Conclusions
- A significant majority of children with chronic HCV exhibit neurodevelopmental disorders.
- This represents a novel finding in pediatric HCV management.
- Healthcare providers should proactively screen for and address neurodevelopmental challenges in children with chronic HCV.
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