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Hepatitis

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

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Updated: May 8, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

Hepatitis B virus quantitative surface antigen levels differ by genotype.

Leon He¹, Alexa Keeshan², Christopher Georgi³

¹Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

Canadian Liver Journal

|November 28, 2025

Summary

This summary is machine-generated.

Hepatitis B virus (HBV) genotype significantly impacts the relationship between HBV DNA and quantitative HBsAg (qHBsAg). Understanding these genotype-specific differences is crucial for developing effective HBV antiviral treatment guidelines.

Keywords:

HBV DNA genotype hepatitis B virus (HBV)quantitative HBsAg

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Area of Science:

Hepatology
Virology
Biochemistry

Background:

Hepatitis B virus (HBV) antiviral treatment relies on HBV DNA levels, liver enzymes, and fibrosis scores.
Quantitative hepatitis B surface antigen (qHBsAg) offers a potentially cost-effective alternative to HBV DNA monitoring.
The impact of HBV genotype on qHBsAg has been underexplored.

Purpose of the Study:

To investigate the correlation between HBV DNA and qHBsAg.
To assess the influence of HBV genotype on this relationship.

Main Methods:

Assessed genotype, HBV DNA, and qHBsAg levels in 138 non-antiviral-treated HBV patients.
Evaluated correlations between HBV DNA and qHBsAg across different HBV genotypes.

Main Results:

HBV DNA and qHBsAg levels varied significantly by genotype (e.g., highest HBV DNA in genotype C, lowest in E; highest qHBsAg in E, lowest in B and C).
The HBV DNA-to-qHBsAg ratio differed in magnitude and direction based on genotype.
Positive correlations between HBV DNA and qHBsAg were observed for genotypes A, B, and D, but not for C and E.
Age, HBeAg status, and genotype independently predicted HBsAg levels and the HBV DNA-to-qHBsAg ratio.

Conclusions:

The relationship between HBV DNA and qHBsAg is genotype-dependent.
These findings are relevant for refining HBV antiviral treatment strategies and guidelines.