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Perfluoroalkyl Chain-Modified Artificial Viral Capsid for Enhanced Intracellular Delivery of mRNA

Avijit Ghosh1, Yuka Yamamoto1, Mizuki Wada1

  • 1Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan.

Bioconjugate Chemistry
|November 28, 2025
PubMed
Summary

Researchers developed a novel peptide-based artificial viral capsid for safe and efficient delivery of messenger RNA (mRNA) therapeutics. This viral-mimetic approach enhances cellular uptake and protein expression while minimizing cytotoxicity, offering a promising alternative for nucleic acid-based medicines.

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