Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

1.3K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
1.3K
General Anesthesia: Overview01:24

General Anesthesia: Overview

552
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
552
Stages of General Anesthesia01:22

Stages of General Anesthesia

1.4K
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
1.4K
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

1.8K
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
1.8K
Local Anesthetics: Chemistry and Structure-Activity Relationship01:30

Local Anesthetics: Chemistry and Structure-Activity Relationship

6.3K
Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
6.3K
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

867
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
867

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

VIR-SAAF: a study protocol for a national decentralised randomised controlled trial of home-based sleep apnoea screening in patients with atrial fibrillation in Denmark.

BMJ open·2026
Same author

Elexacaftor/tezacaftor/ivacaftor is safe and effectively reduces sino-nasal symptoms in people with cystic fibrosis post lung transplantation.

Respiratory medicine·2026
Same author

Penicillin Concentrations in Oropharyngeal and Frontal Sinus Tissue Following Intravenous Bolus and Continuous Infusion - An Experimental Porcine Study.

Pharmaceutical research·2026
Same author

[Chronic obstructive sleep apnoea].

Ugeskrift for laeger·2025
Same author

Ugeskrift for laeger·2025
Same author

Penicillin concentrations in oropharyngeal and frontal sinus tissue following enteral and intravenous administration measured by microdialysis in a porcine model.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2024

Related Experiment Video

Updated: Jan 10, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
08:49

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

14.4K

Local-anaesthesia, one-step sleep surgery.

Jens Krarup1, Jesper Bille2, Milos Fuglsang2

  • 1Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Aalborg University Hospital.

Danish Medical Journal
|November 28, 2025
PubMed
Summary

Outpatient radiofrequency ablation for obstructive sleep apnea (OSA) and snoring showed low complication rates and high patient satisfaction. Procedures improved symptoms for about half of patients, particularly those with non-supine OSA.

More Related Videos

Author Spotlight: Investigating Anesthesia-Induced Sleep Pathways and Neuronal Excitability in Mice
06:37

Author Spotlight: Investigating Anesthesia-Induced Sleep Pathways and Neuronal Excitability in Mice

Published on: October 11, 2024

1.6K
CO2-Lasertonsillotomy Under Local Anesthesia in Adults
05:07

CO2-Lasertonsillotomy Under Local Anesthesia in Adults

Published on: November 6, 2019

25.9K

Related Experiment Videos

Last Updated: Jan 10, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
08:49

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

14.4K
Author Spotlight: Investigating Anesthesia-Induced Sleep Pathways and Neuronal Excitability in Mice
06:37

Author Spotlight: Investigating Anesthesia-Induced Sleep Pathways and Neuronal Excitability in Mice

Published on: October 11, 2024

1.6K
CO2-Lasertonsillotomy Under Local Anesthesia in Adults
05:07

CO2-Lasertonsillotomy Under Local Anesthesia in Adults

Published on: November 6, 2019

25.9K

Area of Science:

  • Otolaryngology
  • Sleep Medicine
  • Minimally Invasive Surgery

Background:

  • Obstructive sleep apnea (OSA) and snoring significantly impact patient quality of life.
  • Current treatments for OSA and snoring have limitations, necessitating novel approaches.
  • Radiofrequency ablation (RFA) offers a minimally invasive option for soft palate and turbinate reduction.

Purpose of the Study:

  • To evaluate the feasibility and effectiveness of outpatient RFA-SP and RFA-T under local anesthesia for OSA and snoring.
  • To assess patient satisfaction and symptom improvement following the procedures.
  • To identify patient subgroups who benefit most from RFA treatment.

Main Methods:

  • Prospective case series of 72 patients with OSA (Apnea-Hypopnoea Index > 5) and/or snoring.
  • Procedures included radiofrequency ablation-assisted soft palate volumetric tissue reduction (RFA-SP) and turbinoplasty (RFA-T) under local anesthesia.
  • Outcomes assessed via cardiorespiratory monitoring (CRM), Snore Index (SI), Epworth Sleepiness Scale, and quality of life questionnaires.

Main Results:

  • The procedures demonstrated low morbidity and high patient satisfaction.
  • Approximately 50% of patients experienced symptom improvement.
  • Improvements in AHI and SI were most notable in non-supine positions.

Conclusions:

  • Outpatient RFA-SP and RFA-T are effective in improving symptoms and quality of life for patients with OSA and snoring.
  • Complete symptom resolution was observed in selected cases.
  • Optimal patient selection, particularly for non-supine OSA, is crucial for best outcomes.