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Updated: Jan 10, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
Published on: July 17, 2019
[Corrigendum] RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK
Zi-Hao Qi1, Hua-Xiang Xu1, Shi-Rong Zhang1
1Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
Abstract:
Following the publication of the above paper, it was drawn to the Editor's attention by an interested reader that the middle and right‑hand protein blots shown for the RIPK4 data in Fig. 2B (relating to the PANC‑1‑Rsh1 and PANC‑1‑Rsh2 experiments) were strikingly similar to western blot data shown in Fig. 3B for the RAF‑1 data (and the same PANC‑1‑Rsh1 and PANC‑1‑Rsh2 experiments), albeit the bands were presented with different exposures/a change in contrast, also with apparent horizontal flipping and vertical resizing. Upon contacting the authors, they realized that errors had been made during the assembly of the experimental images presented in Fig. 3B. These errors were likely to have resulted from oversights made during the process of data consolidation and figure assembly; specifically, this led to the inadvertent use of incorrect images for the RAF‑1 western blot results in both the PANC‑1 cell line (as was correctly identified by the interested reader on PubPeer) and in the Capan‑1 cell line (which the authors identified themselves upon performing their own subsequent review). The authors were also able to present photos of the raw, unedited versions of the gels to the Editorial Office. A revised version of Fig. 3, now showing the correct data for the RAF‑1 blots for both the PANC‑1 and Capan‑1 cell lines, as specified above, is shown on the next page. The authors confirm that the errors made in assembling Fig. 3 did not have a major impact on the conclusions reported in the above article, and they thank the Editor of International Journal of Oncology for allowing them the opportunity to publish a Corrigendum. Furthermore, all the authors agree to the publication of this Corrigendum, and apologize to the readers for any inconvenience caused. [International Journal of Oncology 52: 1105‑1116, 2018; DOI: 10.3892/ijo.2018.4269].
Insights
This corrigendum addresses errors in western blot images for RAF-1 data in Fig. 3B. The authors have issued a corrected figure, confirming no major impact on the study's conclusions.
Area of Science:
- Oncology
- Molecular Biology
- Scientific Publishing Ethics
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