[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen1, Fang Chen2, Ting-Ting Zhang3

  • 1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China.

Insights

This study on salt-inducible kinase 1 in ovarian cancer was retracted due to concerns about western blot data integrity. The authors could not retrieve original experimental data, leading to the paper

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Concerns were raised regarding the western blot data presented in Fig. 1A.
  • Specifically, the β-actin loading controls for patients 4, 6, and 7 showed striking similarities.

Purpose of the Study:

  • To address concerns about data integrity and potential image duplication.
  • To investigate the expression levels of salt-inducible kinase 1 in ovarian cancer tissues.

Main Methods:

  • Western blot analysis was used to detect protein expression.
  • Comparison of experimental data with previously published and retracted studies was performed.

Main Results:

  • Striking similarities were observed in the β-actin loading controls for specific patients.
  • Several protein bands in the western blot appeared similar to data from another published paper, which has since been retracted.

Conclusions:

  • The authors were unable to retrieve a portion of the original experimental data.
  • The paper has been retracted due to unresolved data integrity issues.

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