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Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues
Jin-Long Chen1, Fang Chen2, Ting-Ting Zhang3
1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China.
Abstract:
Following the publication of this paper, a concerned reader drew to the Editor's attention that, regarding the western blots shown in Fig. 1A, where the expression levels of salt‑inducible kinase 1 were detected in ovarian cancer tissues, the β‑actin loading controls for patients 4, 6 and 7 were strikingly similar in appearance [also note that, in view of having not received a timely response to this query from the authors, an Expression of concern (DOI: 10.3892/ijmm.2025.5627) was published for this paper]. Moreover, several of the protein bands in this figure were strikingly similar to data which subsequently appeared in another paper written by different authors at different research institutes that was also published in the journal Experimental and Therapeutic Medicine, although this paper has since been retracted. The authors have subsequently replied to say that they are unable to retrieve a portion of the original experimental data, and therefore wish to retract this paper. All the authors agree with the retraction of this article. Both the authors and the Editor of International Journal of Molecular Medicine apologize to the readership for any inconvenience caused. [International Journal of Molecular Medicine 37: 1601‑1610, 2016; DOI: 10.3892/ijmm.2016.2553].
Insights
This study on salt-inducible kinase 1 in ovarian cancer was retracted due to concerns about western blot data integrity. The authors could not retrieve original experimental data, leading to the paper
Area of Science:
- Molecular Biology
- Oncology
- Biochemistry
Background:
- Concerns were raised regarding the western blot data presented in Fig. 1A.
- Specifically, the β-actin loading controls for patients 4, 6, and 7 showed striking similarities.
Purpose of the Study:
- To address concerns about data integrity and potential image duplication.
- To investigate the expression levels of salt-inducible kinase 1 in ovarian cancer tissues.
Main Methods:
- Western blot analysis was used to detect protein expression.
- Comparison of experimental data with previously published and retracted studies was performed.
Main Results:
- Striking similarities were observed in the β-actin loading controls for specific patients.
- Several protein bands in the western blot appeared similar to data from another published paper, which has since been retracted.
Conclusions:
- The authors were unable to retrieve a portion of the original experimental data.
- The paper has been retracted due to unresolved data integrity issues.
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