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Updated: Jan 10, 2026

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Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 2. General Practices
Published on: October 3, 2016
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The SAFE Labs Handbook as a tool for improving lab culture
Erika Donà1, James M Gahan2, Petrina Lau3
1Institute of Neuroscience, Consiglio Nazionale delle Ricerche (CNR), Vedano al Lambro, Italy.
Elife
|November 28, 2025
Summary
The SAFE Labs Handbook offers 30 commitments for improving lab culture, developed by scientists for scientists. While highly valued, current implementation is low, but adoption is anticipated to increase.
Area of Science:
- Life Sciences Research
- Scientific Community
Background:
- Growing priority for positive and equitable lab environments.
- Institutions offer training, but limited resources exist for group leaders to improve lab culture.
- Need for practical tools for enhancing research environments.
Purpose of the Study:
- Introduce the SAFE Labs Handbook, a resource for improving research culture.
- Detail 30 collaboratively developed commitments for life science group leaders.
- Assess researcher perceptions and intended use of these commitments.
Main Methods:
- Collaborative development of 30 commitments by 13 European group leaders.
- Survey of over 200 researchers across various career stages.
- Analysis of commitment importance and reported/intended implementation rates.
Main Results:
- All 30 commitments were rated as significantly important by researchers.
- Low current implementation rates (<25%) for most commitments.
- High willingness (>95%) among group leaders to consider implementing commitments.
Conclusions:
- The SAFE Labs Handbook is a community-driven tool to enhance lab culture.
- Despite low initial uptake, there is strong potential for widespread adoption.
- This handbook can contribute to improving scientific research environments globally.
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