Genetic Polymorphism of MDM2 Gene Associates with Breast Cancer Incidence in the Lower Northern Thailand

Breast cancer remains the most prevalence among women worldwide, including those in lower northern Thailand. This study aimed to investigate the association between selected genetic polymorphisms and breast cancer incidence in this regional population.

DNA samples were obtained from 184 breast cancer patients and 176 healthy controls. Twelve biallelic genetic markers across nine genes were genotyped using PCR-RFLP, TaqMan probe, and KASP-PCR genotyping assays. Allelic frequencies were calculated for each marker, and odds ratios (OR) was used to assess the association between genetic polymorphism and breast cancer risk.

Among the loci studied, only the deletion allele of MDM2 rs150550023 showed a significant association with breast cancer risk in the lower northern Thai population (OR = 1.44; 95 % CI = 1.033 - 2.008, p = 0.016). This allele was found at a high frequency (23.3%).

These findings suggest that the deletion allele of MDM2 rs150550023 may serve as a potential genetic marker for breast cancer susceptibility in the lower norther Thai population.