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Updated: Jan 10, 2026

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
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Combining an antibiotic stewardship program with a 15-pathogen viral panel to reduce inappropriate antibiotic

Cosby G Arnold1, Tyra Furtado2, Heejung Bang3

  • 1Department of Emergency Medicine, UC Davis School of Medicine, Sacramento, California, USA.

Microbiology Spectrum
|November 28, 2025
PubMed

Insights

Implementing a point-of-care respiratory viral panel with antimicrobial stewardship programs significantly reduced unnecessary antibiotic and steroid prescribing for acute upper respiratory tract infections in urgent care settings.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Clinical Microbiology

Background:

  • Acute upper respiratory tract infections (ARI) often lead to inappropriate antibiotic use, fueling antibiotic resistance.
  • Antimicrobial stewardship programs (ASPs) show promise but are underutilized in urgent care.
  • The impact of point-of-care (POC) respiratory viral panels on prescribing practices is not well-established.

Purpose of the Study:

  • To evaluate the effect of the BIOFIRE SPOTFIRE Respiratory Panel combined with ASP interventions on antibiotic prescribing in urgent care.
  • To assess the impact on inappropriate antibiotic use and steroid prescribing.

Main Methods:

  • Prospective cohort study in a high-volume urgent care setting in the Southeast US (June-August 2024).
  • Intervention group: BIOFIRE SPOTFIRE Respiratory Panel testing and integrated ASP.
  • Control group: Seasonally matched historical usual care.

Main Results:

  • The intervention group showed significantly lower antibiotic prescribing rates (24.3% vs 38.2%).
  • Inappropriate antibiotic use was reduced (15.9% vs 30.8%).
  • Steroid prescribing also decreased significantly (17.9% vs 29.0%).

Conclusions:

  • POC multirespiratory pathogen testing combined with ASP interventions effectively reduces antibiotic prescribing in urgent care.
  • This strategy is crucial for combating antibiotic resistance and improving patient outcomes.
Keywords:
antibiotic stewardshippoint-of-care testingupper respiratory tract infections

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