Related Experiment Video
Updated: Jan 10, 2026

Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer
Published on: October 4, 2022
Chemotherapy-induced neutropenia as a prognostic factor in pancreatic cancer: a systematic review and meta-analysis
Patrick Nogueira de Oliveira Diogo1, Amandha Doro Lerco1, Anna Duenha Garanhani1
1School of Medicine, Universidade Estadual de Mato Grosso do Sul (UEMS), Campo Grande, Brazil.
Background:
Chemotherapy-induced neutropenia (CIN) may reflect higher pharmacodynamic exposure and relate to improved outcomes, but its clinical relevance in pancreatic cancer remains uncertain.
Methods:
PROSPERO-registered, PRISMA-compliant systematic review and meta-analysis. PubMed, Embase, and CENTRAL were searched to 18 August 2025. Eligible studies compared OS in CIN ≥G3 vs
Results:
Eight observational studies met inclusion; five (all advanced disease) were meta-analyzed. CIN ≥G3 was associated with better OS (grouped HR 0.50; 95% CI 0.40-0.62; I2 = 0%), with consistent direction across studies. Sensitivity analyses confirmed robustness. ROBINS-I rated four studies at serious and four at moderate risk of bias; GRADE certainty for the pooled OS effect was moderate.
Conclusions:
In advanced pancreatic cancer, CIN ≥G3 is associated with improved OS, supporting its role as a cohort-level prognostic/pharmacodynamic marker. Generalizability is limited by predominantly Japanese cohorts. Prospective multicenter studies with time-dependent modeling and control of relative dose intensity.
Registration:
www.crd.york.ac.uk/prospero, identifier CRD420251005347.
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