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Analysis of TyG index and TG/HDL ratio with hyperuricemia in patients with H-type hypertension

Ziqiang Luo1, Jie Yang2, Changyi Wang2

  • 1Shenzhen Nanshan Center for Chronic Disease Control. Guangdong Medical University.

Nutricion Hospitalaria
|November 28, 2025
PubMed

Insights

The TyG index and TG/HDL ratio may predict hyperuricemia in H-type hypertension patients. These metabolic indices show stronger predictive power in females, aiding in early risk assessment.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Syndrome Research
  • Biomarker Discovery

Background:

  • Hyperuricemia and hypertension frequently coexist, posing a significant public health challenge.
  • Identifying reliable predictive markers for this comorbidity is crucial for effective management.

Purpose of the Study:

  • To investigate the association between hyperuricemia and two metabolic indices: the triglyceride-glucose (TyG) index and the triglyceride/high-density lipoprotein (TG/HDL) cholesterol ratio.
  • To conduct a gender-specific analysis in patients with H-type hypertension.

Main Methods:

  • Analysis of data from 7,051 patients in a stroke risk screening program (2017-2018, 2021-2023).
  • Utilized logistic regression and restricted cubic spline modeling to assess risk and dose-response relationships.

Main Results:

  • Elevated TyG index and TG/HDL ratio were linked to increased hyperuricemia risk, particularly in females.
  • Observed nonlinear and linear dose-response relationships for TyG index with hyperuricemia in males and females, respectively.
  • TG/HDL ratio demonstrated a nonlinear association with hyperuricemia in both genders. No correlation with homocysteine levels was found.

Conclusions:

  • The TyG index and TG/HDL ratio show potential as predictive biomarkers for hyperuricemia in H-type hypertension.
  • These indices may be particularly valuable for risk prediction in female patients.
Abstract

Keywords:
Hiperuricemia. Hipertensión tipo H. Resistencia a la insulina. Índice triglicéridos-glucosa. Relación triglicéridos/colesterol de lipoproteínas de alta densidad. Multimorbilidad.

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