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Transcriptomic analysis reveals Rnd1 to be a key player in antiviral immunity against Akabane virus via the TNF-α

Dongjie Chen1, Jingjing Wang1, Chao Sun2

  • 1Institute of Animal Inspection and Quarantine, Chinese Academy of Quality and Inspection & Testing, No. 11, Ronghuanan Road, Beijing, 100176, China.

Archives of Virology
|November 28, 2025
PubMed
Summary

Akabane virus (AKAV) infection in bovine cells activates antiviral responses and upregulates inflammatory genes. Rnd1, a key gene, was found to inhibit AKAV replication, offering insights into host defense mechanisms against this virus.

Keywords:
Akabane virusRnd1TNF-α signaling pathwayTranscriptomic analysis

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