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Interaction between morphine and reinforcing lateral hypothalamic stimulation.

K Ornstein, J P Huston

    Psychopharmacology
    |November 15, 1977
    PubMed
    Summary
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    Morphine affects brain reward pathways, altering self-stimulation behaviors in rats. Addiction can change morphine

    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology
    • Addiction Research

    Background:

    • The lateral hypothalamus is a key brain region involved in reward and motivation.
    • Morphine, an opioid, interacts with reward pathways, influencing motivated behaviors.
    • Understanding morphine's effects on self-stimulation is crucial for addiction research.

    Purpose of the Study:

    • To investigate the interaction between morphine administration and lateral hypothalamic self-stimulation in rats.
    • To examine how morphine affects the threshold for self-stimulation in both nonaddicted and addicted rats.
    • To explore the role of external stimulation and shaping in maintaining self-stimulation behavior under morphine influence.

    Main Methods:

    • Rats were subjected to three experiments involving lateral hypothalamic self-stimulation.

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  • Morphine was administered at various doses (2 mg/kg, 8 mg/kg, 16 mg/kg) to nonaddicted rats.
  • Addicted rats received a higher dose (200 mg/kg) of morphine, with thresholds measured at different time points.
  • Some nonaddicted rats received noncontingent priming stimulation and shaping to maintain lever pressing.

    • Main Results:

    • Moderate morphine doses (8 mg/kg) transiently increased the self-stimulation threshold in nonaddicted rats.
    • Low doses (2 mg/kg) had no significant effect on the self-stimulation threshold.
    • In addicted rats, self-stimulation thresholds were lower 2 hours post-morphine compared to 22 hours.
    • A 16 mg/kg morphine dose suppressed self-stimulation, but priming and shaping maintained lever pressing.
    • Rats not receiving priming or shaping showed better recovery (higher response rate) post-injection.

    Conclusions:

    • Morphine's effects on self-stimulation thresholds are dose-dependent and differ between nonaddicted and addicted states.
    • External support (priming, shaping) can override morphine-induced suppression of self-stimulation but may hinder recovery.
    • These findings highlight the complex interplay between opioids, reward circuitry, and motivated behavior.