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Updated: Jan 10, 2026

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
Published on: February 8, 2020
The pulvinar regulates plasticity in human visual cortex
Miriam Acquafredda1, Jan W Kurzawski2, Laura Biagi3
1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Abstract:
In normally sighted human adults, 2 hours of monocular deprivation is sufficient to transiently alter ocular dominance. Here, we show that this is associated with a reduction of functional connectivity between the pulvinar and primary visual cortex (V1), selective for the pulvinar-to-V1 directionality. Across participants, the strength of the pulvinar-to-V1 connectivity was negatively correlated with the ocular dominance shift, implying less plasticity in participants with stronger influence of the pulvinar over V1. Our results support a revised model of adult V1 plasticity, where short-term reorganization is gated by modulatory signals relayed by the pulvinar.
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