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Intra-Operative Radiotherapy with Photons - Update of a Single Institution Registry Trial.

Caroline Oska1, Eleni Kohilakis2, Sheldon Feldman1

  • 1Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY.

Clinical Breast Cancer
|November 28, 2025
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Summary
This summary is machine-generated.

Intraoperative radiotherapy (IORT) offers a safe alternative for early-stage breast cancer, achieving a 97.4% locoregional control rate. This treatment spares most women from whole breast irradiation toxicity, enhancing personalized care.

Keywords:
Breast cancerEarly-stage breast cancerIORTPartial breast irradiationRadiation therapy

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Area of Science:

  • Oncology
  • Radiotherapy
  • Breast Cancer Treatment

Background:

  • Intraoperative radiotherapy (IORT) integrates radiation delivery with breast-conserving surgery (BCS) for early-stage breast cancer.
  • This study updates outcomes for women treated with IORT in New York.

Purpose of the Study:

  • To evaluate the efficacy and safety of IORT as an adjuvant treatment for early-stage breast cancer.
  • To assess locoregional recurrence rates, overall survival, and wound-healing complications in patients receiving IORT.

Main Methods:

  • A prospective, single-center registry trial involving 257 women aged 45+ with specific early-stage breast cancer types.
  • Patients received a single 20 Gy dose of IORT via the Intrabeam system.
  • Exclusion criteria included BRCA mutations, neoadjuvant chemotherapy, or multicentric disease.

Main Results:

  • Over a median follow-up of 3.7 years, 7 recurrences (2.6%) and 10 wound complications (3.9%) were observed.
  • Overall survival was high at 97.3%.
  • 16.6% of patients were recommended adjuvant whole breast irradiation (WBI) for high-risk features.

Conclusions:

  • IORT demonstrated a 97.4% locoregional control rate, offering a safe alternative to traditional whole breast irradiation.
  • The treatment spared 83.4% of women from the toxicity associated with WBI.
  • IORT supports personalized treatment approaches for eligible early-stage breast cancer patients.