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Related Experiment Video

Updated: Jan 10, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
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Published on: May 30, 2025

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Understanding changes in complex care needs over time: key research insights into multimorbidity trajectories.

Amaia Calderón-Larrañaga1, Elisa Fabbri2, Ana Isabel González3

  • 1Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden.

The Lancet. Healthy Longevity
|November 28, 2025
PubMed
Summary

Understanding multimorbidity trajectories is crucial for better healthcare. Longitudinal studies tracking disease progression offer new insights for personalized interventions and improved patient outcomes in aging populations.

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Last Updated: Jan 10, 2026

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05:10

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877

Area of Science:

  • Gerontology
  • Public Health
  • Epidemiology

Background:

  • Multimorbidity, the co-occurrence of multiple chronic conditions, presents a significant global health challenge.
  • Current research predominantly uses cross-sectional studies, limiting understanding of disease evolution over time.
  • A shift towards longitudinal research is needed to capture the dynamic nature of multimorbidity.

Purpose of the Study:

  • To advocate for a paradigm shift towards longitudinal approaches in multimorbidity research.
  • To guide future research on the dynamic processes underlying multimorbidity trajectories.
  • To identify key themes and findings from expert discussions on advancing multimorbidity research.

Main Methods:

  • Expert discussions from an international workshop.
  • Review of existing literature and data resources on multimorbidity.
  • Identification of challenges and opportunities in longitudinal multimorbidity research.

Main Results:

  • Longitudinal approaches are essential for understanding multimorbidity evolution.
  • Key themes include standardizing phenotypes, integrating care processes, and validating trajectory usefulness.
  • Methodological innovation, patient involvement, data harmonization, and collaboration are vital.

Conclusions:

  • A trajectory-based framework can enhance understanding of disease accumulation.
  • This framework supports personalized, efficient, and equitable healthcare strategies.
  • Advancing multimorbidity research requires interdisciplinary collaboration and methodological advancements.