Related Experiment Video

Updated: Jan 10, 2026

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
07:53

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Published on: March 17, 2020

7.6K

Cavin-3 promotes TNF expression via the MAPK signaling pathway in lung squamous cell carcinoma

Xiaoyan Xu1, Yonghong Nie2, Jiatuo Xu1

  • 1School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Biochimica Et Biophysica Acta. General Subjects
|November 28, 2025
PubMed

Insights

Cavin-3 protein inhibits lung squamous cell carcinoma (LUSC) progression by regulating inflammatory factors via the MAPK pathway. This finding highlights Cavin-3 as a potential diagnostic marker and therapeutic target for LUSC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cavin family proteins influence tumor cell invasiveness.
  • Limited research exists on the specific role and mechanisms of Cavins in cancer pathogenesis.
  • A knowledge gap necessitates a detailed investigation into Cavin proteins' functions in tumorigenesis.

Purpose of the Study:

  • To systematically analyze the mechanism of action of Cavins in cancer.
  • To evaluate Cavin-3's diagnostic value in lung squamous cell carcinoma (LUSC).
  • To explore Cavin-3 as a potential therapeutic target for LUSC.

Main Methods:

  • Bioinformatic analysis to identify molecular mechanisms.
  • In vitro experiments to validate biological functions.
  • Assessment of Cavin-3 expression and its correlation with LUSC progression.

Main Results:

  • Cavin-3 was found to inhibit LUSC tumor cells.
  • Cavin-3 regulates EREG and IL1A expression, activating the MAPK pathway.
  • Activation of MAPK pathway promotes the release of tumor necrosis factor (TNF) and inflammatory factors, inhibiting tumor proliferation.

Conclusions:

  • Cavin-3 plays a significant role in inhibiting LUSC progression.
  • Cavin-3 acts by modulating the MAPK signaling pathway and inflammatory responses.
  • Cavin-3 presents potential as a diagnostic biomarker and therapeutic target for LUSC.
Keywords:
Cavin-3Lung squamous carcinomaTumor necrosis factor

More Related Videos

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin10:21

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

7.6K
Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System08:54

Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System

Published on: March 20, 2016

10.2K

Related Concept Videos

MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
7.8K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
9.7K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.4K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
680
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.2K
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
8.2K