Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

2.0K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.0K
Subviral Agents01:29

Subviral Agents

475
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
475
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.6K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

49.2K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From clinical fluids to environmental matrices: quantitative monitoring of infectious monkeypox virus based on PMA-qPCR during the Guangdong outbreak.

Tropical medicine and health·2026
Same author

GULP1 enhances GLUT4 translocation by counteracting ACAP1-ARF6 inhibition.

Nutrition & diabetes·2026
Same author

Associations between intrinsic capacity, subjectively perceived environmental support and functional status among rural disabled older adults in China: guided by the healthy ageing framework.

BMC public health·2026
Same author

Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model.

Exploration (Beijing, China)·2026
Same author

[Current status of intrauterine adhesion treatment and research progress in stem cell therapy].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
Same author

Bioinformatics identification of copyback and multihost-adapted defective viral genomes in dengue virus.

Frontiers in cellular and infection microbiology·2026

Related Experiment Video

Updated: Jan 10, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.0K

Antiviral agents for dengue virus.

Yinghan Jiang1, Yanran Wang2, Yaqun Xu3

  • 1School of Interdisciplinary Science, Beijing Institute of Technology, Beijing 100081, China; School of Life Science, Beijing Institute of Technology, Beijing 100081, China; Key Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing 100081, China.

Virologica Sinica
|November 28, 2025
PubMed
Summary

Dengue virus (DENV) poses a global health threat, with challenges in vaccine development and no specific antiviral treatments. This review explores DENV characteristics and new antiviral strategies to combat outbreaks.

Keywords:
Antiviral agentsDengue virusFlavivirusPeptides drugs

More Related Videos

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
08:36

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

32.5K
Assays for the Identification of Novel Antivirals against Bluetongue Virus
12:02

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

14.5K

Related Experiment Videos

Last Updated: Jan 10, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.0K
Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
08:36

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

32.5K
Assays for the Identification of Novel Antivirals against Bluetongue Virus
12:02

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

14.5K

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Dengue virus (DENV) is a mosquito-borne pathogen causing significant global morbidity and mortality.
  • Nearly 50% of the world's population is at risk of DENV infection.
  • Challenges in dengue control include limited cross-protection among serotypes and antibody-dependent enhancement (ADE), alongside a lack of specific antiviral therapies.

Purpose of the Study:

  • To provide a comprehensive overview of Dengue virus (DENV) characteristics and clinical manifestations.
  • To review recent advancements in the development of antiviral drugs against DENV.
  • To offer insights for managing and preventing dengue outbreaks.

Main Methods:

  • Literature review of DENV characteristics, clinical aspects, and antiviral drug development.
  • Analysis of various antiviral strategies, including drug repurposing, peptide agents, antibodies, natural products, and host factor inhibitors.

Main Results:

  • DENV infection presents a spectrum of illnesses, from dengue fever to severe dengue hemorrhagic fever and shock syndrome.
  • Current challenges include limited serotype cross-protection and the complicating factor of antibody-dependent enhancement (ADE).
  • Emerging antiviral approaches encompass repurposed drugs, novel peptide-based agents, therapeutic antibodies, natural compounds, and host factor inhibitors.

Conclusions:

  • Effective dengue control is hampered by viral complexities and the absence of specific treatments.
  • Ongoing research into diverse antiviral strategies shows promise for future dengue management.
  • This review highlights critical insights for developing effective interventions against dengue virus (DENV).