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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

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Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

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Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

244
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
244
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Association Of Rehospitalization After Pediatric Kidney Transplantation With Kidney Function At 1-year Posttransplant And Long-term Allograft Failure.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Association Of Rehospitalization After Pediatric Kidney Transplantation With Kidney Function At 1-year Posttransplant And Long-term Allograft Failure.

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Association of rehospitalization after pediatric kidney transplantation with kidney function at 1-year posttransplant and long-term allograft failure.

Eric G Benz1, Justin Godown2, Doug Schaubel3

  • 1Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA; Division of Nephrology, Children's Hospital Colorado, Aurora, Colorado, USA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|November 28, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
kidney transplantpediatricsrehospitalization

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Over two-thirds of pediatric kidney transplant (KT) recipients experience rehospitalization within a year. This early rehospitalization is linked to worse kidney function and long-term graft failure, highlighting a need for preventative strategies.

Area of Science:

  • Pediatric Nephrology
  • Transplant Surgery
  • Health Services Research

Background:

  • Rehospitalization after pediatric kidney transplant (KT) is frequent but not well understood.
  • Understanding rehospitalization patterns is crucial for improving outcomes in pediatric KT recipients.

Purpose of the Study:

  • To determine the frequency, causes, and risk factors for rehospitalization within the first year post-pediatric KT.
  • To investigate the association between first-year rehospitalization and long-term graft outcomes and kidney function.

Main Methods:

  • Utilized linked data from the Scientific Registry for Transplant Recipients and Pediatric Health Information System databases.
  • Analyzed rehospitalization rates, causes, and associated risk factors across 36 pediatric hospitals.
  • Examined the impact of rehospitalization on estimated glomerular filtration rate (eGFR) and death-censored allograft failure at 10 years.

    • Main Results:

    • 69% of pediatric KT recipients were rehospitalized within the first year.
    • Common causes included urologic/anatomical/surgical issues, infections, and renal/electrolyte problems.
    • First-year rehospitalization was associated with younger age, Black race, public insurance, longer index hospitalization, worse 1-year eGFR, and increased risk of long-term allograft failure (HR 1.38).

    Conclusions:

    • First-year rehospitalization is a significant issue in pediatric KT, impacting graft survival and kidney function.
    • Identifying preventable hospitalizations is essential for quality improvement initiatives.
    • Further research is needed to develop targeted interventions to reduce rehospitalization rates and improve long-term outcomes.