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Severe Cardiomegaly in Congestive Heart Failure: Postmortem Evidence of Cardiac Remodeling

Ty R Mote1, Christopher T Scroggins1, Alexis Gillett2

  • 1Arkansas College of Osteopathic Medicine, Fort Smith, Arkansas, USA.

JACC. Case Reports
|November 28, 2025
PubMed

Insights

Postmortem examination revealed significant cardiac remodeling and left ventricular hypertrophy in a donor with heart failure, supporting a hypertensive cause. This case highlights the structural basis of heart failure.

Area of Science:

  • Cardiovascular Pathology
  • Cardiac Remodeling
  • Gross Anatomy

Background:

  • Cardiomegaly signifies advanced cardiac remodeling due to hemodynamic stress.
  • Direct postmortem examination of cardiac remodeling is infrequent.
  • Clinical diagnosis of cardiomegaly typically relies on radiologic imaging.
Abstract

Keywords:
atrial fibrillationcardiomyopathychronic heart failurehypertension

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