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Related Concept Videos

CRISPR01:59

CRISPR

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
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Microorganisms in Medicine and Therapeutics01:29

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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Updated: Jan 10, 2026

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
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Pharmacogenomics and CRISPR-based therapies.

Maham Fatima1, Ieman Tariq2, Ayesha Tariq2

  • 1Department of Zoology, The Government Sadiq College Women University, Bahawalpur, Pakistan.

Progress in Brain Research
|November 28, 2025
PubMed
Summary
This summary is machine-generated.

Precision medicine advances with pharmacogenomics and CRISPR gene editing, personalizing drug treatments and enabling curative therapies for diseases like cancer. This synergy offers a proactive approach to healthcare.

Keywords:
CRISPRDrug responseGene editingPharmacogenomics

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Area of Science:

  • Genetics
  • Pharmacology
  • Biotechnology

Background:

  • Pharmacogenomics analyzes genetic variations to tailor drug efficacy and minimize adverse reactions.
  • CRISPR-Cas systems offer precise genome editing capabilities for targeted genetic alterations.

Purpose of the Study:

  • To explore the synergistic relationship between CRISPR-based treatments and pharmacogenomics.
  • To highlight applications in pharmacoresistance, cancer, and monogenic diseases.
  • To address ethical, legal, and technical considerations for safe implementation.

Main Methods:

  • Review of theoretical and practical frameworks linking CRISPR and pharmacogenomics.
  • Analysis of recent applications in various disease contexts.
  • Examination of ethical, legal, and technical challenges.

Main Results:

  • CRISPR technology enhances pharmacogenomics by enabling gene expression modification and mutation correction.
  • The combination facilitates personalized and potentially curative drug development.
  • Applications show promise in treating pharmacoresistant conditions, cancers, and monogenic disorders.

Conclusions:

  • The integration of CRISPR and pharmacogenomics represents a significant leap in precision medicine.
  • This synergy paves the way for individualized therapies and novel treatment strategies.
  • Addressing associated challenges is crucial for equitable and effective deployment.