Genetic and epigenetic drivers of neurodegenerative disorders

Neurodegenerative illnesses such as Alzheimer's disease, Parkinson's disease, and Huntington's disease present with increasing neurodegeneration and derangement. Genomic mutations and epigenetic changes are known to be part of their causation. This particular chapter discusses the key genetic factors like APP, SNCA, HTT, and C9orf72 mutations that influence the development and course of the disease. Furthermore, we examine epigenetic mechanisms-DNA methylation, histone modification, and non-coding RNAs-that regulate gene expression and contribute to neuronal susceptibility. The discussion also focuses on environmental and behavioral factors that affect the epigenome, highlighting gene-environment interactions. Advancements in omics technology and integrative studies have enhanced comprehension of biological pathways and uncovered novel biomarkers and therapeutic targets. The chapter therefore integrates epigenetic and genetic viewpoints to elucidate the intricate regulatory processes responsible for neurodegeneration and highlights potential avenues for early diagnosis, precision medicine, and therapeutic interventions aimed at remodeling disease pathways.