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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Longitudinal Research02:20

Longitudinal Research

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Related Experiment Video

Updated: Jan 10, 2026

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
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Predicting healthspan and disease risks through biological age.

Gen Li1, Linling Cheng2, Io Nam Wong2

  • 1State Key Laboratory of Eye Health, Clinical Data Science Institute, Institute for Advanced Study on Eye Health and Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Trends in Molecular Medicine
|November 28, 2025
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Aging is a universal decline in body function. New research explores aging clocks to measure biological age, offering hope for extending healthspan and improving life quality.

Keywords:
age gapaging clocksbiological agehealthspan

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Area of Science:

  • Gerontology and molecular biology

Background:

  • Aging is a natural, progressive decline in physiological functions affecting all individuals.
  • While chronological age (CA) is standard, it doesn't fully capture functional health.
  • Specific genes and diet impact aging, highlighting key molecular pathways.

Purpose of the Study:

  • To explore aging hallmarks beyond chronological age.
  • To investigate the potential of aging clocks in assessing biological age (BA).
  • To understand how aging clocks can inform healthspan extension strategies.

Main Methods:

  • Review of research on aging hallmarks and lifespan extension.
  • Analysis of factors influencing senescence and physiological decline.
  • Evaluation of aging clocks for predicting biological age.

Main Results:

  • Aging involves progressive impairments across multiple physiological systems.
  • Telomere shortening and other hallmarks offer better functional decline measures than CA.
  • Aging clocks more accurately predict biological age (BA) than CA.

Conclusions:

  • Aging clocks provide a precise measure of physiological health.
  • Developing therapies targeting aging mechanisms can extend healthspan.
  • Aging clocks are crucial for improving quality of life in an aging global population.