Related Experiment Video
Updated: Jul 25, 2026

08:49
Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Interaction between narcotic antagonist (naloxone) and lysergic acid diethylamide (LSD) in the rat
Psychopharmacology
|November 15, 1977
Abstract:
LSD administration in rats elicited a diphasic reaction consisting of a brief excitable period ( up to 8 min) followed by a prolonged catalepsy (8 min-1 h). While the cataleptic response was antagonized by a single injection of naloxone (given 30 min after LSD administration), pretreatment with naloxone shortened the excitable phase and potentiated the catalepsy.
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