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Effectiveness of Boric Acid in Sepsis in Rats with Cecal Perforation
Ali Can Kurtipek1, Ali Doğan Dursun2, Zeynep Yığman3
1Faculty of Medicine, Department of Internal Medicine, Ankara University, Ankara, Türkiye. ackurtipek@ankara.edu.tr.
Biological Trace Element Research
|November 28, 2025
Summary
High-dose boric acid (BA) treatment in rats with sepsis (induced by cecal ligation and puncture) reduced kidney and lung tissue damage. This study suggests BA may mitigate sepsis-induced organ injury.
Area of Science:
- Sepsis research
- Toxicology
- Pharmacology
Background:
- Sepsis causes systemic inflammation and end-organ damage.
- Boric acid (BA) exhibits immune modulatory effects in vitro and in animal models.
Purpose of the Study:
- To evaluate the protective effects of high-dose boric acid on lung and kidney tissues in a rat model of sepsis.
Main Methods:
- Sepsis was induced in rats using cecal ligation and puncture (CLP).
- Rats were divided into control, boric acid, CLP, and CLP + boric acid groups.
- Boric acid was administered intraperitoneally at 200 mg/kg.
- Kidney and lung tissues were analyzed for biochemical and histopathological changes after 24 hours.
Main Results:
- Boric acid administration significantly reduced peritubular capillary dilatation and brush border loss in kidney tubules.
- In lung tissue, boric acid treatment led to significantly less alveolar wall thickening.
- Biochemical analysis revealed reduced oxidative stress in both renal and lung tissues of the CLP + BA group.
Conclusions:
- High-dose boric acid administration partially ameliorated sepsis-induced tissue damage in rat kidneys and lungs.
- Further research is warranted to determine optimal BA dosage and administration timing for sepsis treatment.
