Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

368
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
368
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

440
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
440
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

296
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
296

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting lifetime cardiovascular risk and benefits of preventive treatment in patients with established atherosclerotic cardiovascular disease: the SMART-REACH2 model.

European heart journal·2026
Same author

Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology.

Nature aging·2026
Same author

Changes in device-measured daily physical activity over one year in memory clinic patients.

European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity·2026
Same author

Corrigendum to "Changes in sedentary behavior in the chronic phase following stroke" [Journal of Stroke and Cerebrovascular Diseases Volume 33, Issue 8, August 2024, 107827].

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same author

Vitamin B6 predicts poor outcomes in geographically distinct populations with primary sclerosing cholangitis.

Journal of hepatology·2026
Same author

Improving 10-year cardiovascular risk prediction in patients with established cardiovascular disease: flexible addition of risk predictors on top of the SMART2 risk score.

European journal of preventive cardiology·2026
Same journal

Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.

Scientific reports·2026
Same journal

Microbial contamination of donor corneas and post-keratoplasty endophthalmitis: a comparison between Japanese and U.S. eye banks using cold storage.

Scientific reports·2026
Same journal

Prevalence and contributing factors of virological non-suppression among adult patients on first-line antiretroviral therapy in tertiary hospitals in Ethiopia.

Scientific reports·2026
Same journal

An in vitro comparison of color stability between alkasite and different restorative materials in various staining solutions.

Scientific reports·2026
Same journal

Toward accessible mRNA LNP formulation: systematic evaluation of mixing strategies and key parameters.

Scientific reports·2026
Same journal

A network analysis of personality traits, mentalizing, and psychological health in Chinese college students.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

409

Associations between systemic inflammation and cognitive trajectories post-stroke.

Heidi Vihovde Sandvig1,2, Ingvild Saltvedt3,4, Trine Holt Edwin5

  • 1Department of Medicine, Kristiansund Hospital, Sjukehuset Nordmøre og Romsdal, Møre og Romsdal Hospital Trust, Kristiansund, Norway. Heidi.V.Sandvig@ntnu.no.

Scientific Reports
|November 29, 2025
PubMed
Summary
This summary is machine-generated.

Higher levels of inflammation markers in the acute phase after stroke are linked to worse cognitive trajectories and declining cognitive function. These findings highlight the role of systemic inflammation in post-stroke cognitive impairment.

Keywords:
Cognitive trajectoriesFrailtyIschemic strokeSystemic inflammationThe terminal C5b-9 complement complexTumour necrosis factor

More Related Videos

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.6K
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

36.0K

Related Experiment Videos

Last Updated: Jan 10, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

409
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.6K
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

36.0K

Area of Science:

  • Neuroscience
  • Immunology
  • Gerontology

Background:

  • Cognitive impairment is a common and serious consequence of stroke.
  • Understanding the factors influencing cognitive trajectories post-stroke is crucial for developing targeted interventions.
  • Systemic inflammation is increasingly recognized as a potential contributor to stroke-related brain damage and cognitive decline.

Purpose of the Study:

  • To investigate the association between plasma inflammatory biomarkers and related metabolites in the acute phase and 3 months post-stroke with different cognitive trajectories.
  • To determine if these biomarkers and metabolites are associated with changes in cognitive function over time after stroke.

Main Methods:

  • Prospective, multicentre cohort study (Norwegian Cognitive Impairment After Stroke - Nor-COAST) with 466 participants.
  • Cognitive trajectories modeled using Montreal Cognitive Assessment (MoCA) scores.
  • Multinomial logistic regression and mixed linear regression used to analyze associations between biomarkers and cognitive outcomes, stratified by pre-stroke cognitive status.

Main Results:

  • Higher acute-phase levels of terminal complement complex, interleukin 6, macrophage inflammatory protein 1α, neopterin, quinolinic acid, and PA ratio were associated with a higher risk of low and declining MoCA scores.
  • Higher 3-month neopterin levels were also linked to worse cognitive trajectories.
  • Elevated acute-phase tumor necrosis factor and interleukin 8 were associated with progressive decline in MoCA scores.
  • Pre-stroke frailty significantly impacted the models, confounding some associations.

Conclusions:

  • Elevated systemic inflammation in the acute phase post-stroke is associated with worse cognitive trajectories and decline.
  • These inflammatory markers may reflect the body's response to the acute stroke, complications, or pre-existing conditions.
  • Premorbid factors, particularly frailty, play a substantial role in post-stroke cognitive outcomes.