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Application of statistical design of experiment to identify key factors in cross coupling reactions

Fulufhelo Radzilani1, Orpah Zinyemba1, Reinout Meijboom2

  • 1Department of Chemical Science, University of Johannesburg, Auckland Park, Johannesburg, 2006, South Africa.

Scientific Reports
|November 29, 2025
PubMed

Keywords:
CatalysisMizoroki–Heck reactionOne-Factor-At-A-Time (OFAT)Plackett–Burman design (PBD)Sonogashira–Hagihara reactionStatistical design of experiment (sDoE)Suzuki–Miyaura reaction

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